TM4SF1 Polyclonal Antibody
- 货号：YT4675
- 应用：IHC;IF;ELISA
- 种属：Human;Mouse
- 蛋白名称：
- Transmembrane 4 L6 family member 1
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human T4S1. AA range:1-50
- 特异性：
- TM4SF1 Polyclonal Antibody detects endogenous levels of TM4SF1 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- TM4SF1;M3S1;TAAL6;Transmembrane 4 L6 family member 1;Membrane component chromosome 3 surface marker 1;Tumor-associated antigen L6
- 背景：
- The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008],
- 功能：
- similarity:Belongs to the L6 tetraspanin family.,subunit:Present in high molecular weight complexes in tumor cells.,tissue specificity:Highly expressed on lung, breast, colon, and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.,
- 细胞定位：
- Membrane; Multi-pass membrane protein. Colocalizes with SDCBP2 in the apical region of the cell (PubMed:11102519). .
- 组织表达：
- Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.
- Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using T4S1 Antibody. The picture on the right is blocked with the synthesized peptide.
