• 靶点：
• TLE4

• 简介：
• >>Wnt signaling pathway;>>Notch signaling pathway

• 基因名称：
• TLE4

• 蛋白名称：
• Transducin-like enhancer protein 4

• Human Gene Id：
• 7091

• Human Swiss Prot No：
• Q04727

• Mouse Gene Id：
• 21888

• Mouse Swiss Prot No：
• Q62441

• Rat Gene Id：
• 25565

• Rat Swiss Prot No：
• Q07141

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human TLE4. AA range:161-210

• 特异性：
• TLE4 Polyclonal Antibody detects endogenous levels of TLE4 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• TLE4;KIAA1261;Transducin-like enhancer protein 4

• 实测条带：
• 83kD

• 背景：
• caution:Product of a dubious CDS prediction. Found in the 3'UTR of TLE4. No homolog. Large scale identification of a phosphorylated peptide (PubMed:15302935) would require further confirmation.,function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.,similarity:Belongs to the WD repeat Groucho/TLE family.,similarity:Contains 7 WD repeats.,subunit:Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2.,tissue specificity:In all tissues examined, mostly in brain, and muscle.,

• 功能：
• caution:Product of a dubious CDS prediction. Found in the 3'UTR of TLE4. No homolog. Large scale identification of a phosphorylated peptide (PubMed:15302935) would require further confirmation.,function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.,similarity:Belongs to the WD repeat Groucho/TLE family.,similarity:Contains 7 WD repeats.,subunit:Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2.,tissue specificity:In all tissues examined, mostly in brain, and muscle.,

• 细胞定位：
• Nucleus.

• 组织表达：
• In all tissues examined, mostly in brain, and muscle.

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