TIRAP Polyclonal Antibody

    • 货号:YT4667
    • 应用:IHC;IF;WB;ELISA
    • 种属:Human;Mouse
      • 靶点:
      • TIRAP
      • 简介:
      • >>NF-kappa B signaling pathway;>>Toll-like receptor signaling pathway;>>Alcoholic liver disease;>>Pathogenic Escherichia coli infection;>>Salmonella infection;>>Pertussis;>>Tuberculosis;>>Hepatitis B;>>PD-L1 expression and PD-1 checkpoint pathway in cancer;>>Lipid and atherosclerosis
      • 基因名称:
      • TIRAP
      • 蛋白名称:
      • Toll/interleukin-1 receptor domain-containing adapter protein
      • Human Swiss Prot No:
      • P58753
      • Mouse Swiss Prot No:
      • Q99JY1
      • 免疫原:
      • The antiserum was produced against synthesized peptide derived from human TIRAP. AA range:52-101
      • 特异性:
      • TIRAP Polyclonal Antibody detects endogenous levels of TIRAP protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • TIRAP;MAL;Toll/interleukin-1 receptor domain-containing adapter protein;TIR domain-containing adapter protein;Adaptor protein Wyatt;MyD88 adapter-like protein
      • 分子量:
      • 24kD
      • 背景:
      • The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008],
      • 功能:
      • function:Adapter involved in the TLR4 signaling pathway in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, resulting in cytokine secretion and the inflammatory response.,polymorphism:Genetic variation in TIRAP can influence susceptibility or resistance to invasive pneumococcal disease, bacteremia, malaria and tuberculosi.,similarity:Contains 1 TIR domain.,subunit:Homodimer. Also forms heterodimers with MyD88. Binds to TLR4 and IRAK2 via their respective TIR domains. Binds to PKR and TBK1. Does not interact with IRAK1, nor TLR9.,tissue specificity:Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.,
      • 细胞定位:
      • Cytoplasm . Cell membrane . Membrane . Colocalizes with DAB2IP at the plasma membrane.
      • 组织表达:
      • Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.

      Phycocyanin Exerts Anti-Proliferative Effects through Down-Regulating TIRAP/NF-κB Activity in Human Non-Small Cell Lung Cancer Cells. Cells Cells-Basel. 2019 Jun;8(6):588 WB Human H1975 cell, H1650 cell,LTEP-a2 cell
      货号:YT4667

      • 产品图片
      • Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.