• 靶点：
• TIMAP

• 基因名称：
• PPP1R16B

• 蛋白名称：
• Protein phosphatase 1 regulatory inhibitor subunit 16B

• Human Gene Id：
• 26051

• Human Swiss Prot No：
• Q96T49

• Mouse Gene Id：
• 228852

• Mouse Swiss Prot No：
• Q8VHQ3

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human PPP1R16B. AA range:364-413

• 特异性：
• TIMAP Polyclonal Antibody detects endogenous levels of TIMAP protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PPP1R16B;ANKRD4;KIAA0823;Protein phosphatase 1 regulatory inhibitor subunit 16B;Ankyrin repeat domain-containing protein 4;CAAX box protein TIMAP;TGF-beta-inhibited membrane-associated protein;hTIMAP

• 实测条带：
• 64kD

• 背景：
• The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015],

• 功能：
• function:May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.,induction:Inhibited by TGF-beta1.,similarity:Contains 5 ANK repeats.,subunit:Binds PP1.,tissue specificity:Highly expressed in vascular endothelium, CNS, lung, spleen, kidney and testis.,

• 细胞定位：
• Cell membrane . Cell membrane ; Lipid-anchor . Nucleus . Cell projection . Colocalizes with RPSA/LAMR1 in the cell membrane (PubMed:16263087). Localizes to the perinuclear region (By similarity). Colocalizes with PTEN at the tip of EC projections (PubMed:25007873). .

• 组织表达：
• Brain,

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