• 靶点：
• TFIIA-α

• 简介：
• >>Basal transcription factors;>>Viral carcinogenesis

• 基因名称：
• GTF2A1

• 蛋白名称：
• Transcription initiation factor IIA subunit 1

• Human Gene Id：
• 2957

• Human Swiss Prot No：
• P52655

• Mouse Gene Id：
• 83602

• Mouse Swiss Prot No：
• Q99PM3

• Rat Gene Id：
• 83830

• Rat Swiss Prot No：
• O08949

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human TF2A1. AA range:281-330

• 特异性：
• TFIIA-α Polyclonal Antibody detects endogenous levels of TFIIA-α protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GTF2A1;TF2A1;Transcription initiation factor IIA subunit 1;General transcription factor IIA subunit 1;TFIIAL;Transcription initiation factor TFIIA 42 kDa subunit;TFIIA-42

• 实测条带：
• 42kD

• 背景：
• Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010],

• 功能：
• function:TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.,PTM:The alpha and beta subunits are postranslationally produced from the precursor form by TASP1. The cleavage promotes proteosomal degradation.,similarity:Belongs to the TFIIA subunit 1 family.,subunit:TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). TFIIA forms a complex with TBP.,

• 细胞定位：
• Nucleus.

• 组织表达：
• Epithelium,

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