• 靶点：
• TEL

• 简介：
• >>Transcriptional misregulation in cancer

• 基因名称：
• ETV6

• 蛋白名称：
• Transcription factor ETV6

• Human Gene Id：
• 2120

• Human Swiss Prot No：
• P41212

• Mouse Swiss Prot No：
• P97360

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Tel. AA range:223-272

• 特异性：
• TEL Polyclonal Antibody detects endogenous levels of TEL protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ETV6;TEL;TEL1;Transcription factor ETV6;ETS translocation variant 6;ETS-related protein Tel1;Tel

• 实测条带：
• 55kD

• 背景：
• This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008],

• 功能：
• disease:A chromosomal aberration involving ETV6 is a cause in many instances of chronic myeloproliferative disorder with eosinophilia (MPE) [MIM:131440]. Translocation t(5;12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein.,disease:A chromosomal aberration involving ETV6 is a cause of acute lymphoblastic leukemia. Translocation t(9;12)(p13;p13) with PAX5.,disease:A chromosomal aberration involving ETV6 is a cause of myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with MDS2.,disease:A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML).,disease:A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid leukemia. Translocation

• 细胞定位：
• Nucleus.

• 组织表达：
• Ubiquitous.

The adaptor protein 14-3-3zeta modulates intestinal immunity and aging in Drosophila. JOURNAL OF BIOLOGICAL CHEMISTRY Mingyao Yang WB Flies，Human 293T cell
货号：YT4600

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