T2R43 Polyclonal Antibody
- 货号：YT4510
- 应用：WB;ELISA
- 种属：Human
- 蛋白名称：
- Taste receptor type 2 member 43
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human TAS2R43. AA range:124-173
- 特异性：
- T2R43 Polyclonal Antibody detects endogenous levels of T2R43 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- TAS2R43;Taste receptor type 2 member 43;T2R43;Taste receptor type 2 member 52;T2R52
- 背景：
- TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009],
- 功能：
- function:Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Activated by the sulfonyl amide sweeteners saccharin and acesulfame K.,miscellaneous:Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.,similarity:Belongs to the G-protein coupled receptor T2R family.,tissue specificity:Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.,
- 细胞定位：
- Membrane ; Multi-pass membrane protein . Cell projection, cilium membrane . In airway epithelial cells, localizes to motile cilia.
- 组织表达：
- Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Expressed in airway epithelia.
- Western blot analysis of TAS2R43 Antibody. The lane on the right is blocked with the TAS2R43 peptide.
- Western blot analysis of the lysates from COLO205 cells using TAS2R43 antibody.
