T2R16 Polyclonal Antibody
- 货号：YT4507
- 应用：WB;IF;ELISA
- 种属：Human;Rat;Mouse;
- 蛋白名称：
- Taste receptor type 2 member 16
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human TAS2R16. AA range:136-185
- 特异性：
- T2R16 Polyclonal Antibody detects endogenous levels of T2R16 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- TAS2R16;Taste receptor type 2 member 16;T2R16
- 背景：
- This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008],
- 功能：
- function:Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.,miscellaneous:Confers bitter perception of salicin to non-taster mice.,miscellaneous:Several bitter taste receptors are expressed in a single taste receptor cell.,polymorphism:The Lys-172 polymorphism in TAS2R16 is associated with genetic susceptibility to alcoholism [MIM:103780].,similarity:Belongs to the G-protein coupled receptor T2R family.,tissue specificity:Expressed in a subset of gustducin-positive taste receptor cells of the tongue.,
- 细胞定位：
- Cell membrane ; Multi-pass membrane protein .
- 组织表达：
- Expressed in a subset of gustducin-positive taste receptor cells of the tongue. Expressed in circumvallate papillae and testis (PubMed:16720576).
- Western blot analysis of lysates from MCF-7 cells, using TAS2R16 Antibody. The lane on the right is blocked with the synthesized peptide.
