StIp1 Polyclonal Antibody
- 货号：YT4459
- 应用：WB;IHC
- 种属：Human;Rat;Mouse;
- 蛋白名称：
- Elongator complex protein 2
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human ELP2. AA range:771-820
- 特异性：
- StIp1 Polyclonal Antibody detects endogenous levels of StIp1 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500-2000;IHC 1:50-300
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- ELP2;STATIP1;Elongator complex protein 2;ELP2;SHINC-2;STAT3-interacting protein 1;StIP1
- 背景：
- The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. [provided by RefSeq, May 2016],
- 功能：
- function:Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.,function:Regulates the ligand-dependent activation of STAT3.,similarity:Belongs to the WD repeat ELP2 family.,similarity:Contains 14 WD repeats.,subunit:Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with STAT3 and JAKs.,
- 细胞定位：
- Cytoplasm . Nucleus .
- 组织表达：
- Hematopoietic,Liver,Ovary,Uterus,
- Western Blot analysis of various cells using StIp1 Polyclonal Antibody
- Western blot analysis of lysates from HT-29 cells, using ELP2 Antibody. The lane on the right is blocked with the synthesized peptide.
- Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
