• 靶点：
• Stat5a

• 简介：
• >>ErbB signaling pathway;>>Necroptosis;>>JAK-STAT signaling pathway;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>Prolactin signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>Growth hormone synthesis, secretion and action;>>Hepatitis B;>>Measles;>>Human T-cell leukemia virus 1 infection;>>Pathways in cancer;>>Viral carcinogenesis;>>Chemical carcinogenesis - receptor activation;>>Chronic myeloid leukemia;>>Acute myeloid leukemia;>>Non-small cell lung cancer

• 基因名称：
• STAT5A

• 蛋白名称：
• Signal transducer and activator of transcription 5A

• Human Gene Id：
• 6776

• Human Swiss Prot No：
• P42229

• Mouse Gene Id：
• 20850

• Mouse Swiss Prot No：
• P42230

• Rat Gene Id：
• 24918

• Rat Swiss Prot No：
• Q62771

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human STAT5A. AA range:745-794

• 特异性：
• Stat5a Polyclonal Antibody detects endogenous levels of Stat5a protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• STAT5A;STAT5;Signal transducer and activator of transcription 5A

• 实测条带：
• 91kD

• 背景：
• The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been

• 功能：
• function:Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.,online information:STAT5 entry,PTM:Tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL-15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus in response to phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7.,

• 细胞定位：
• Cytoplasm . Nucleus . Translocated into the nucleus in response to phosphorylation.

• 组织表达：
• Brain,Cervix,Epithelium,Lung,Placenta,Synovial memb

Targeting androgen receptor with ASC-J9 attenuates cardiac injury and dysfunction in experimental autoimmune myocarditis by reducing M1-like macrophage. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Biochem Bioph Res Co. 2017 Apr;485:746 WB Mouse 1:500 Raw264.7 macrophages
货号：YT4452

Relationship between coronary artery calcification and calcium deposition in the myocardium:. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 2019 May 22 WB Human myocardial tissue
货号：YT4452

Targeting androgen receptor with ASC-J9 attenuates cardiac injury and dysfunction in experimental autoimmune myocarditis by reducing M1-like macrophage. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Biochem Bioph Res Co. 2017 Apr;485:746 WB Mouse 1:500 Raw264.7 macrophages
货号：YT4452

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