SSTR4 Polyclonal Antibody
- 货号：YT4430
- 应用：WB;ELISA
- 种属：Human;Mouse;Rat
- 简介：
- >>Neuroactive ligand-receptor interaction
- 蛋白名称：
- Somatostatin receptor type 4
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human SSTR4. AA range:155-204
- 特异性：
- SSTR4 Polyclonal Antibody detects endogenous levels of SSTR4 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- SSTR4;Somatostatin receptor type 4;SS-4-R;SS4-R;SS4R
- 背景：
- Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008],
- 功能：
- function:Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.,
- 细胞定位：
- Cell membrane; Multi-pass membrane protein.
- 组织表达：
- Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.
- Western blot analysis of lysates from LOVO cells, using SSTR4 Antibody. The lane on the right is blocked with the synthesized peptide.
- Western blot analysis of the lysates from HepG2 cells using SSTR4 antibody.
