• 靶点：
• SR-1B

• 简介：
• >>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Serotonergic synapse;>>Taste transduction

• 基因名称：
• HTR1B

• 蛋白名称：
• 5-hydroxytryptamine receptor 1B

• Human Gene Id：
• 3351

• Human Swiss Prot No：
• P28222

• Mouse Gene Id：
• 15551

• Mouse Swiss Prot No：
• P28334

• Rat Gene Id：
• 25075

• Rat Swiss Prot No：
• P28564

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human 5-HT-1B. AA range:201-250

• 特异性：
• SR-1B Polyclonal Antibody detects endogenous levels of SR-1B protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• HTR1B;HTR1DB;5-hydroxytryptamine receptor 1B;5-HT-1B;5-HT1B;S12;Serotonin 1D beta receptor;5-HT-1D-beta;Serotonin receptor 1B

• 实测条带：
• 43kD

• 背景：
• The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015],

• 功能：
• function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.,PTM:Palmitoylated.,PTM:Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation.,similarity:Belongs to the G-protein coupled receptor 1 family.,

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein .

• 组织表达：
• Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen.

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