• 靶点：
• SR-1A

• 简介：
• >>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Serotonergic synapse;>>Taste transduction

• 基因名称：
• HTR1A

• 蛋白名称：
• 5-hydroxytryptamine receptor 1A

• Human Gene Id：
• 3350

• Human Swiss Prot No：
• P08908

• Mouse Gene Id：
• 15550

• Mouse Swiss Prot No：
• Q64264

• Rat Gene Id：
• 24473

• Rat Swiss Prot No：
• P19327

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human 5-HT-1A. AA range:291-340

• 特异性：
• SR-1A Polyclonal Antibody detects endogenous levels of SR-1A protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• HTR1A;ADRB2RL1;ADRBRL1;5-hydroxytryptamine receptor 1A;5-HT-1A;5-HT1A;G-21;Serotonin receptor 1A

• 实测条带：
• 46kD

• 背景：
• This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012],

• 功能：
• function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.,similarity:Belongs to the G-protein coupled receptor 1 family.,

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein . Cell projection, dendrite .

• 组织表达：
• Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.

A unique inflammation-related mechanism by which high-fat diets induce depression-like behaviors in mice. Haining Yu WB Mouse 1:1000 hippocampus
货号：YT4391

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