- 靶点：
- SIP1
- 简介：
- >>MicroRNAs in cancer
- 基因名称：
- ZEB2
- 蛋白名称：
- Zinc finger E-box-binding homeobox 2
- Human Gene Id：
- 9839
- Human Swiss Prot No：
- O60315
- Mouse Gene Id：
- 24136
- Mouse Swiss Prot No：
- Q9R0G7
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human ZEB2. AA range:71-120
- 特异性：
- SIP1 Polyclonal Antibody detects endogenous levels of SIP1 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度：
- 1 mg/ml
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- ZEB2;KIAA0569;SIP1;ZFHX1B;ZFX1B;HRIHFB2411;Zinc finger E-box-binding homeobox 2;Smad-interacting protein 1;SMADIP1;Zinc finger homeobox protein 1b
- 实测条带：
- 157kD
- 背景：
- The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010],
- 功能：
- disease:Defects in ZEB2 are the cause of Hirschsprung disease-mental retardation syndrome (Hirschsprung disease) [MIM:235730]; also known as Mowat-Wilson syndrome (MWS). Hirschsprung disease is a rare autosomal dominant complex developmental disorder. Individuals with functional null mutations present with mental retardation, delayed motor development, epilepsy, and a wide spectrum of clinically heterogeneous features suggestive of neurocristopathies at the cephalic, cardiac, and vagal levels. Affected patients show an easily recognizable facial appearance with deep set eyes and hypertelorism, medially divergent, broad eyebrows, prominent columella, pointed chin and uplifted, notched ear lobes. Additionally, the phenotypic spectrum of facultative congenital anomalies includes short stature, microcephaly, Hirschsprung disease, malformations of the brain (agenesis of corpus callosum, cereb
- 细胞定位：
- Nucleus . Chromosome .
- 组织表达：
- Brain,Fetal brain,
miRNA miR-147a targets ZEB2 to regulate ox-LDL-induced monocyte adherence to HUVECs, atherosclerotic plaque formation and stability in atherosclerosis JOURNAL OF BIOLOGICAL CHEMISTRY Hongwei Dan IF Mouse aortic arch
货号：YT4300
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- Antibody-FAQs
- 产品图片
- Western Blot analysis of various cells using SIP1 Polyclonal Antibody diluted at 1:1000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
- Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ZEB2 Antibody. The picture on the right is blocked with the synthesized peptide.
- Western blot analysis of lysates from Jurkat cells, using ZEB2 Antibody. The lane on the right is blocked with the synthesized peptide.
- Western blot analysis of the lysates from HepG2 cells using ZEB2 antibody.
