Septin 5 Polyclonal Antibody
- 货号：YT4249
- 应用：WB;IHC
- 种属：Human;Mouse;Rat
- 简介：
- >>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases
- 免疫原：
- Synthesized peptide derived from Septin 5 . at AA range: 180-260
- 特异性：
- Septin 5 Polyclonal Antibody detects endogenous levels of Septin 5 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500-2000;IHC 1:50-300
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- SEPT5;PNUTL1;Septin-5;Cell division control-related protein 1;CDCrel-1;Peanut-like protein 1
- 背景：
- septin 5(SEPT5) Homo sapiens This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010],
- 功能：
- function:Involved in cytokinesis .,similarity:Belongs to the septin family.,subunit:May assemble into a multicomponent structure.,
- 细胞定位：
- Cytoplasm . Cytoplasm, cytoskeleton . In platelets, found in areas surrounding alpha-granules.
- 组织表达：
- Expressed at high levels in the CNS, as well as in heart and platelets (at protein level).
- Western blot analysis of lysates from DU145 cells, primary antibody was diluted at 1:1000, 4°over night
- Immunohistochemical analysis of paraffin-embedded human uterus. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
