SEMA3A Polyclonal Antibody
- 货号：YT4232
- 应用：IHC;IF;ELISA
- 种属：Human;Mouse;Rat
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human SEMA3A. AA range:688-737
- 特异性：
- SEMA3A Polyclonal Antibody detects endogenous levels of SEMA3A protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- SEMA3A;SEMAD;Semaphorin-3A;Semaphorin III;Sema III
- 背景：
- This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008],
- 功能：
- domain:Strong binding to neuropilin is mediated by the carboxy third of the protein.,function:Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.,similarity:Belongs to the semaphorin family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 PSI domain.,similarity:Contains 1 Sema domain.,
- 组织表达：
- Expressed in the dorsal root ganglia.
- Immunohistochemistry analysis of SEMA3A antibody in paraffin-embedded human tonsil tissue.
