• 靶点：
• SDF-1

• 简介：
• >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>NF-kappa B signaling pathway;>>Axon guidance;>>Leukocyte transendothelial migration;>>Intestinal immune network for IgA production;>>Regulation of actin cytoskeleton;>>Human cytomegalovirus infection;>>Pathways in cancer;>>Rheumatoid arthritis

• 基因名称：
• CXCL12

• 蛋白名称：
• Stromal cell-derived factor 1

• Human Gene Id：
• 6387

• Human Swiss Prot No：
• P48061

• Mouse Gene Id：
• 20315

• Mouse Swiss Prot No：
• P40224

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human SDF-1. AA range:44-93

• 特异性：
• SDF-1 Polyclonal Antibody detects endogenous levels of SDF-1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IF 1:50-200 WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CXCL12;SDF1;SDF1A;SDF1B;Stromal cell-derived factor 1;SDF-1;hSDF-1;C-X-C motif chemokine 12;Intercrine reduced in hepatomas;IRH;hIRH;Pre-B cell growth-stimulating factor;PBSF

• 实测条带：
• 10-20kD,

• 背景：
• C-X-C motif chemokine ligand 12(CXCL12) Homo sapiens This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014],

• 功能：
• function:Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites.,online information:SDF-1 entry,PTM:Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processsed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,

• 细胞定位：
• Secreted.

• 组织表达：
• Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen.

Estrogen-induced SDF-1α production promotes the progression of ER-negative breast cancer via the accumulation of MDSCs in the tumor microenvironment. Scientific Reports Sci Rep-Uk. 2016 Dec;6(1):1-10 WB,IHC Mouse 1:50 4T1 +EMT6 cell-tumor
货号：YT4225

Depot-specific inflammation with decreased expression of ATM2 in white adipose tissues induced by high-margarine/lard intake. PLoS One Plos One. 2017 Nov;12(11):e0188007 WB Rat 1:2000 epididymal, retroperitoneal ,subcutaneous fat tissues
货号：YT4225

C-X-C chemokine receptor type 7 antibody enhances neural plasticity after ischemic stroke Neural Regeneration Research Shan-Shan Zhao WB Rat striatum
货号：YT4225

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