• 靶点：
• Sarcoglycan-β

• 简介：
• >>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy;>>Viral myocarditis

• 基因名称：
• SGCB

• 蛋白名称：
• Beta-sarcoglycan

• Human Gene Id：
• 6443

• Human Swiss Prot No：
• Q16585

• Mouse Gene Id：
• 24051

• Mouse Swiss Prot No：
• P82349

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Sarcoglycan-beta. AA range:87-136

• 特异性：
• Sarcoglycan-β Polyclonal Antibody detects endogenous levels of Sarcoglycan-β protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• SGCB;Beta-sarcoglycan;Beta-SG;43 kDa dystrophin-associated glycoprotein;43DAG;A3b

• 实测条带：
• 43kD

• 背景：
• This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008],

• 功能：
• disease:Defects in SGCB are the cause of limb-girdle muscular dystrophy type 2E (LGMD2E) [MIM:604286]. LGMD2E is an autosomal recessive disorder.,function:Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.,online information:SGCB mutations in LGMD2E,PTM:Disulfide bonds are present.,similarity:Belongs to the sarcoglycan beta/delta/gamma/zeta family.,subunit:Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.,tissue specificity:Highest expression in heart and skeletal muscle. Low expression in brain, kidney, placenta, pancreas and lung. High expression in fetal brain. Also found in

• 细胞定位：
• Cell membrane, sarcolemma ; Single-pass type II membrane protein . Cytoplasm, cytoskeleton .

• 组织表达：
• Highest expression in heart and skeletal muscle. Low expression in brain, kidney, placenta, pancreas and lung. High expression in fetal brain. Also found in fetal lung, kidney and liver.

Sacubitril/Valsartan Alleviates Experimental Autoimmune Myocarditis by Inhibiting Th17 Cell Differentiation Independently of the NLRP3 Inflammasome Pathway. Frontiers in Pharmacology Front Pharmacol. 2021; 12: 727838 WB Mouse 1:1000 Myocardial tissues
货号：YT4216

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