• 靶点：
• RXRγ

• 简介：
• >>PPAR signaling pathway;>>Th17 cell differentiation;>>Thyroid hormone signaling pathway;>>Adipocytokine signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Chemical carcinogenesis - receptor activation;>>Thyroid cancer;>>Small cell lung cancer;>>Non-small cell lung cancer;>>Gastric cancer;>>Lipid and atherosclerosis

• 基因名称：
• RXRG

• 蛋白名称：
• Retinoic acid receptor RXR-gamma

• Human Gene Id：
• 6258

• Human Swiss Prot No：
• P48443

• Mouse Gene Id：
• 20183

• Mouse Swiss Prot No：
• P28705

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Retinoid X Receptor gamma. AA range:171-220

• 特异性：
• RXRγ Polyclonal Antibody detects endogenous levels of RXRγ protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• RXRG;NR2B3;Retinoic acid receptor RXR-gamma;Nuclear receptor subfamily 2 group B member 3;Retinoid X receptor gamma

• 实测条带：
• 50kD

• 背景：
• retinoid X receptor gamma(RXRG) Homo sapiens This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010],

• 功能：
• caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,function:Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA).,similarity:Belongs to the nuclear hormone receptor family. NR2 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,

• 细胞定位：
• Nucleus . Cytoplasm .

• 组织表达：
• Expressed in aortic endothelial cells (at protein level).

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