• 靶点：
• RAP1

• 基因名称：
• TERF2IP

• 蛋白名称：
• Telomeric repeat-binding factor 2-interacting protein 1

• Human Gene Id：
• 54386

• Human Swiss Prot No：
• Q9NYB0

• Mouse Swiss Prot No：
• Q91VL8

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human RAP1. AA range:203-252

• 特异性：
• RAP1 Polyclonal Antibody detects endogenous levels of RAP1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• TERF2IP;DRIP5;RAP1;PP8000;Telomeric repeat-binding factor 2-interacting protein 1;TERF2-interacting telomeric protein 1;TRF2-interacting telomeric protein 1;Dopamine receptor-interacting protein 5;Repressor/activator protein 1 homol

• 实测条带：
• 55kD

• 背景：
• The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010],

• 功能：
• function:May play a role in telomere length regulation. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.,miscellaneous:Recruited to telomeres by TRF2; seemingly it does not directly bind to DNA itself.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Translated as Glu.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 Myb-like domain.,subcellular location:Colocalizes with telomeric DNA in interphase and metaphase cells.,subunit:Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TE

• 细胞定位：
• Nucleus . Cytoplasm . Chromosome . Chromosome, telomere . Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex. .

• 组织表达：
• Ubiquitous. Highly expressed.

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