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RANTES Polyclonal Antibody

货号：YT4002
应用：IHC;IF;ELISA
种属：Human;Mouse;Rat

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靶点：
RANTES

简介：
>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>Toll-like receptor signaling pathway;>>NOD-like receptor signaling pathway;>>Cytosolic DNA-sensing pathway;>>TNF signaling pathway;>>Prion disease;>>Epithelial cell signaling in Helicobacter pylori infection;>>Shigellosis;>>Chagas disease;>>Human cytomegalovirus infection;>>Influenza A;>>Herpes simplex virus 1 infection;>>Rheumatoid arthritis;>>Lipid and atherosclerosis

基因名称：
CCL5

蛋白名称：
C-C motif chemokine 5

Human Gene Id：
6352

Human Swiss Prot No：
P13501

Mouse Gene Id：
20304

Mouse Swiss Prot No：
P30882

Rat Swiss Prot No：
P50231

免疫原：
The antiserum was produced against synthesized peptide derived from human RANTES. AA range:35-84

特异性：
RANTES Polyclonal Antibody detects endogenous levels of RANTES protein.

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
CCL5;D17S136E;SCYA5;C-C motif chemokine 5;EoCP;Eosinophil chemotactic cytokine;SIS-delta;Small-inducible cytokine A5;T cell-specific protein P228;TCP228;T-cell-specific protein RANTES

分子量：
10kD

背景：
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode

功能：
function:Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.,induction:By mitogens.,mass spectrometry: PubMed:1380064,mass spectrometry: PubMed:15923218,mass spectrometry:O-glycosylated PubMed:1380064,online

细胞定位：
Secreted.

组织表达：
Expressed in the follicular fluid (at protein level). T-cell and macrophage specific.

HUCMSC-derived Exosomes Suppress the Titanium Particles-induced Osteolysis in Mice through Inhibiting CCL2 and CCL3 Orthopaedic Surgery Yue Ding MD IHC Human hip Synovial membrane
货号：YT4002