- 靶点：
- RAGE
- 简介：
- >>Neutrophil extracellular trap formation;>>AGE-RAGE signaling pathway in diabetic complications;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Diabetic cardiomyopathy;>>Lipid and atherosclerosis
- 基因名称：
- AGER
- 蛋白名称：
- Advanced glycosylation end product-specific receptor
- Human Gene Id：
- 177
- Human Swiss Prot No：
- Q15109
- Mouse Swiss Prot No：
- Q62151
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human RAGE. AA range:133-182
- 特异性：
- RAGE Polyclonal Antibody detects endogenous levels of RAGE protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度：
- 1 mg/ml
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- AGER;RAGE;Advanced glycosylation end product-specific receptor;Receptor for advanced glycosylation end products
- 实测条带：
- 37kD
- 背景：
- The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011],
- 功能：
- function:Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Receptor for amyloid beta peptide.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Endothelial cells.,
- 细胞定位：
- [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 10]: Cell membrane ; Single-pass type I membrane protein .
- 组织表达：
- Endothelial cells.
3-Arylcoumarin inhibits vascular calcification by inhibiting the generation of AGEs and anti-oxidative stress JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY Yanling Mu WB Human
货号：YT3993
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- Antibody-FAQs
- 产品图片
- Western Blot analysis of 3T3 cells using RAGE Polyclonal Antibody diluted at 1:1000
- Immunohistochemistry analysis of RAGE antibody in paraffin-embedded human lung carcinoma tissue.
- Western blot analysis of lysate from LOVO cells, using RAGE antibody.
