PXR Polyclonal Antibody

    • 货号:YT3911
    • 应用:WB;ELISA
    • 种属:Human;Rat;Mouse;
      • 靶点:
      • PXR
      • 基因名称:
      • NR1I2
      • 蛋白名称:
      • Nuclear receptor subfamily 1 group I member 2
      • Human Gene Id:
      • 8856
      • Human Swiss Prot No:
      • O75469
      • Mouse Swiss Prot No:
      • O54915
      • 免疫原:
      • The antiserum was produced against synthesized peptide derived from human NR1I2. AA range:91-140
      • 特异性:
      • PXR Polyclonal Antibody detects endogenous levels of PXR protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • NR1I2;PXR;Nuclear receptor subfamily 1 group I member 2;Orphan nuclear receptor PAR1;Orphan nuclear receptor PXR;Pregnane X receptor;Steroid and xenobiotic receptor;SXR
      • 实测条带:
      • 50kD
      • 背景:
      • This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008],
      • 功能:
      • function:Orphan receptor; its natural ligand is probably pregnane. Binds to a response element in the CYP3A4 and ABCB1/MDR1 genes promoter. Activates its expression in response to a wide variety of endobiotics and xenobiotics.,induction:Activated by naturally occurring steroids such as pregnenolone and progesterone.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Forms a heterodimer with RXR.,tissue specificity:Expressed in liver, colon and small intestine.,
      • 细胞定位:
      • Nucleus .
      • 组织表达:
      • Expressed in liver, colon and small intestine.

      Imidacloprid increases intestinal permeability by disrupting tight junctions. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Ecotox Environ Safe. 2021 Oct;222:112476 WB Rat 1:1000 Intestine
      货号:YT3911

      • 产品图片
      • Zhao, Guo-Ping, et al. "Imidacloprid increases intestinal permeability by disrupting tight junctions." Ecotoxicology and Environmental Safety 222 (2021): 112476.