PRX1 Polyclonal Antibody

    • 货号:YT3874
    • 应用:WB;ELISA
    • 种属:Human;Mouse;Rat
      • 靶点:
      • PRX1
      • 基因名称:
      • PRRX1
      • 蛋白名称:
      • Paired mesoderm homeobox protein 1
      • Human Gene Id:
      • 5396
      • Human Swiss Prot No:
      • P54821
      • Mouse Swiss Prot No:
      • P63013
      • 免疫原:
      • Synthesized peptide derived from PRX1 . at AA range: 30-110
      • 特异性:
      • PRX1 Polyclonal Antibody detects endogenous levels of PRX1 protein.
      • 组成:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源:
      • Polyclonal, Rabbit,IgG
      • 稀释:
      • WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
      • 纯化工艺:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • 浓度:
      • 1 mg/ml
      • 储存:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称:
      • PRRX1;PMX1;Paired mesoderm homeobox protein 1;Homeobox protein PHOX1;Paired-related homeobox protein 1;PRX-1
      • 实测条带:
      • 27kD
      • 背景:
      • The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq, Jul 2008],
      • 功能:
      • function:Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer.,similarity:Belongs to the paired homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 OAR domain.,
      • 细胞定位:
      • Nucleus.

      SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis. CELL DEATH AND DIFFERENTIATION Cell Death Differ. 2021 Jun;:1-15 WB Human PANC-1 cell
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      SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis. CELL DEATH AND DIFFERENTIATION Cell Death Differ. 2021 Jun;:1-15 WB Human PANC-1 cell, AsPC-1 cell
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      The rs7911488-T allele promotes the growth and metastasis of colorectal cancer through modulating miR-1307/PRRX1. Cell Death & Disease Cell Death Dis. 2020 Aug;11(8):1-14 WB Human SW480 cell, HCT-116 cell
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      • 产品图片
      • Yang, M., Liu, X., Meng, F. et al. The rs7911488-T allele promotes the growth and metastasis of colorectal cancer through modulating miR-1307/PRRX1. Cell Death Dis 11, 651 (2020). 
      • Western Blot analysis of various cells using PRX1 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
      • Western Blot analysis of Jurkat cells using PRX1 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).