• 靶点：
• PLCβ3

• 简介：
• >>Inositol phosphate metabolism;>>Metabolic pathways;>>Rap1 signaling pathway;>>Calcium signaling pathway;>>cGMP-PKG signaling pathway;>>Chemokine signaling pathway;>>Phosphatidylinositol signaling system;>>Sphingolipid signaling pathway;>>Phospholipase D signaling pathway;>>Adrenergic signaling in cardiomyocytes;>>Vascular smooth muscle contraction;>>Wnt signaling pathway;>>Apelin signaling pathway;>>Gap junction;>>Platelet activation;>>Neutrophil extracellular trap formation;>>NOD-like receptor signaling pathway;>>Circadian entrainment;>>Long-term potentiation;>>Retrograde endocannabinoid signaling;>>Glutamatergic synapse;>>Cholinergic synapse;>>Serotonergic synapse;>>Dopaminergic synapse;>>Long-term depression;>>Taste transduction;>>Inflammatory mediator regulation of TRP channels;>>Insulin secretion;>>GnRH signaling pathway;>>Estrogen signaling pathway;>>Melanogenesis;>>Thyroid hormone synthesis;>>Thyroid hormone signaling pathway;>>Oxytocin signaling pathway;>>Glucagon signaling p

• 基因名称：
• PLCB3

• 蛋白名称：
• 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

• Human Gene Id：
• 5331

• Human Swiss Prot No：
• Q01970

• Mouse Swiss Prot No：
• P51432

• Rat Swiss Prot No：
• Q99JE6

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human PLC beta3. AA range:503-552

• 特异性：
• PLC β3 Polyclonal Antibody detects endogenous levels of PLC β3 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PLCB3;1-phosphatidylinositol 4;5-bisphosphate phosphodiesterase beta-3;Phosphoinositide phospholipase C-beta-3;Phospholipase C-beta-3;PLC-beta-3

• 实测条带：
• 140kD

• 背景：
• This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],

• 功能：
• catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,subunit:Interacts with SHANK2 (By similarity). Interacts with LPAR2.,

• 细胞定位：
• Cytoplasm . Membrane . Nucleus . And particulate fractions. .

• 组织表达：
• Epithelium,Uterus,

Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1 Cell Metabolism Kan Huang WB Rat 1:1000 plasma
货号：YT3790

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