• 靶点：
• PKA Iβ reg

• 简介：
• >>Insulin signaling pathway

• 基因名称：
• PRKAR1B

• 蛋白名称：
• cAMP-dependent protein kinase type I-beta regulatory subunit

• Human Gene Id：
• 5575

• Human Swiss Prot No：
• P31321

• Mouse Gene Id：
• 19085

• Mouse Swiss Prot No：
• P12849

• Rat Swiss Prot No：
• P81377

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human KAP1. AA range:106-155

• 特异性：
• PKA Iβ reg Polyclonal Antibody detects endogenous levels of PKA Iβ reg protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PRKAR1B;cAMP-dependent protein kinase type I-beta regulatory subunit

• 实测条带：
• 43kD

• 背景：
• The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015],

• 功能：
• PTM:The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.,similarity:Belongs to the cAMP-dependent kinase regulatory chain family.,similarity:Contains 2 cyclic nucleotide-binding domains.,subunit:The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules.,tissue specificity:Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.,

• 细胞定位：
• Cell membrane .

• 组织表达：
• Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.

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