• 靶点：
• PFK-C

• 简介：
• >>Glycolysis / Gluconeogenesis;>>Pentose phosphate pathway;>>Fructose and mannose metabolism;>>Galactose metabolism;>>Metabolic pathways;>>Carbon metabolism;>>Biosynthesis of amino acids;>>RNA degradation;>>HIF-1 signaling pathway;>>AMPK signaling pathway;>>Thyroid hormone signaling pathway;>>Glucagon signaling pathway;>>Central carbon metabolism in cancer

• 基因名称：
• PFKP

• 蛋白名称：
• 6-phosphofructokinase type C

• Human Gene Id：
• 5214

• Human Swiss Prot No：
• Q01813

• Mouse Gene Id：
• 56421

• Mouse Swiss Prot No：
• Q9WUA3

• Rat Gene Id：
• 60416

• Rat Swiss Prot No：
• P47860

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human K6PP. AA range:341-390

• 特异性：
• PFK-C Polyclonal Antibody detects endogenous levels of PFK-C protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PFKP;PFKF;6-phosphofructokinase type C;6-phosphofructokinase; platelet type;Phosphofructo-1-kinase isozyme C;PFK-C;Phosphofructokinase 1;Phosphohexokinase

• 实测条带：
• 84kD

• 背景：
• This gene encodes a member of the phosphofructokinase A protein family. The encoded enzyme is the platelet-specific isoform of phosphofructokinase and plays a key role in glycolysis regulation. This gene may play a role in metabolic reprogramming in some cancers, including clear cell renal cell carcinomas, and cancer of the bladder, breast, and lung. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016],

• 功能：
• catalytic activity:ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.,cofactor:Magnesium.,enzyme regulation:Allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate.,miscellaneous:In human PFK exists as a system of 3 types of subunits, PFKM (muscle), PFKL (liver) and PFKP (platelet) isoenzymes.,pathway:Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.,similarity:Belongs to the phosphofructokinase family. Two domains subfamily.,subunit:Tetramer. Muscle is M4, liver is L4, and red cell is M3L, M2L2, or ML3. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts.,

• 细胞定位：
• Cytoplasm .

• 组织表达：
• Brain,Epithelium,Kidney,Pancreatic islet,Placenta,Prostate,

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