PAR-6β Polyclonal Antibody
- 货号：YT3589
- 应用：WB;IHC;IF;ELISA
- 种属：Human;Mouse
- 简介：
- >>Rap1 signaling pathway;>>Endocytosis;>>Axon guidance;>>Hippo signaling pathway;>>Tight junction;>>Human papillomavirus infection
- 蛋白名称：
- Partitioning defective 6 homolog beta
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human PARD6B. AA range:233-282
- 特异性：
- PAR-6β Polyclonal Antibody detects endogenous levels of PAR-6β protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- PARD6B;PAR6B;Partitioning defective 6 homolog beta;PAR-6 beta;PAR-6B
- 背景：
- This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008],
- 功能：
- domain:The PDZ domain mediates interaction with MPP5.,domain:The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.,function:Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.,similarity:Belongs to the PAR6 family.,similarity:Contains 1 OPR domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 pseudo-CRIB domain.,subunit:Interacts with PARD3. Interacts with GTP-bound forms of CDC42 and RAC1. Interacts with GTP-bound ARHQ/TC10. Interacts with MPP5 (By similarity). Interacts with the N-terminal part of PRKCI and
- 细胞定位：
- Cytoplasm. Cell membrane . Cell junction, tight junction .
- 组织表达：
- Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.
- Western blot analysis of lysates from Jurkat cells, using PARD6B Antibody. The lane on the right is blocked with the synthesized peptide.
