• 靶点：
• P2Y4

• 简介：
• >>Neuroactive ligand-receptor interaction;>>Taste transduction

• 基因名称：
• P2RY4

• 蛋白名称：
• P2Y purinoceptor 4

• Human Gene Id：
• 5030

• Human Swiss Prot No：
• P51582

• Mouse Gene Id：
• 57385

• Mouse Swiss Prot No：
• Q9JJS7

• Rat Gene Id：
• 63843

• Rat Swiss Prot No：
• O35811

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human P2RY4. AA range:159-208

• 特异性：
• P2Y4 Polyclonal Antibody detects endogenous levels of P2Y4 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• P2RY4;NRU;P2Y purinoceptor 4;P2Y4;P2P;Uridine nucleotide receptor;UNR

• 实测条带：
• 41kD

• 背景：
• The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008],

• 功能：
• function:Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.,PTM:Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Pancreas.,

• 细胞定位：
• Cell membrane; Multi-pass membrane protein.

• 组织表达：
• Pancreas.

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