- 靶点：
- p19
- 简介：
- >>FoxO signaling pathway;>>Cell cycle
- 基因名称：
- CDKN2D
- 蛋白名称：
- Cyclin-dependent kinase 4 inhibitor D
- Human Gene Id：
- 1032
- Human Swiss Prot No：
- P55273
- Mouse Swiss Prot No：
- Q60773
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human CDKN2D. AA range:96-145
- 特异性：
- p19 Polyclonal Antibody detects endogenous levels of p19 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度：
- 1 mg/ml
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- CDKN2D;Cyclin-dependent kinase 4 inhibitor D;p19-INK4d
- 分子量：
- 18kD
- 背景：
- The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008],
- 功能：
- function:Interacts strongly with CDK4 and CDK6 and inhibits them.,similarity:Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.,similarity:Contains 4 ANK repeats.,
- 细胞定位：
- Nucleus . Cytoplasm .
- 组织表达：
- Bone marrow,Muscle,Platelet,Thymus,
Ginsenoside Rg1 improves fertility and reduces ovarian pathological damages in premature ovarian failure model of mice:. EXPERIMENTAL BIOLOGY AND MEDICINE Exp Biol Med. 2017;242(7):683-691 WB Mouse 1:100 ovaries
货号：YT3496
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- 产品图片
- Immunohistochemistry analysis of paraffin-embedded human brain, using p19 INK4d Antibody. The picture on the right is blocked with the synthesized peptide.
