• 靶点：
• NRF-1

• 简介：
• >>Apelin signaling pathway;>>Huntington disease

• 基因名称：
• NRF1

• 蛋白名称：
• Nuclear respiratory factor 1

• Human Gene Id：
• 4899

• Human Swiss Prot No：
• Q16656

• Mouse Gene Id：
• 18181

• Mouse Swiss Prot No：
• Q9WU00

• Rat Swiss Prot No：
• Q62792

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human NRF1. AA range:221-270

• 特异性：
• NRF-1 Polyclonal Antibody detects endogenous levels of NRF-1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• NRF1;Nuclear respiratory factor 1;NRF-1;Alpha palindromic-binding protein;Alpha-pal

• 实测条带：
• 54kD

• 背景：
• This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014],

• 功能：
• function:Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.,PTM:Phosphorylation enhances DNA binding.,similarity:Belongs to the NRF1/Ewg family.,subunit:Homodimer. Binds DNA as a dimer. Interacts with PPRC1.,tissue specificity:Ubiquitously expressed with strongest expression in skeletal muscle.,

• 细胞定位：
• Nucleus.

• 组织表达：
• Ubiquitously expressed with strongest expression in skeletal muscle.

Low Expression of Sirtuin 1 in the Dairy Cows with Mild Fatty Liver Alters Hepatic Lipid Metabolism. Animals Animals-Basel. 2020 Apr;10(4):560 WB Bovine Liver
货号：YT3188

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