- 靶点：
- NPY
- 简介：
- >>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Adipocytokine signaling pathway;>>Regulation of lipolysis in adipocytes;>>Alcoholism
- 基因名称：
- NPY
- 蛋白名称：
- Pro-neuropeptide Y
- Human Gene Id：
- 4852
- Human Swiss Prot No：
- P01303
- Mouse Gene Id：
- 109648
- Mouse Swiss Prot No：
- P57774
- Rat Gene Id：
- 1.00912e+008
- Rat Swiss Prot No：
- P07808
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human NPY. AA range:45-94
- 特异性：
- NPY Polyclonal Antibody detects endogenous levels of NPY protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- IHC 1:100-500,WB 1:500-2000,ELISA 1:5000-20000. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度：
- 1 mg/ml
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- NPY;Pro-neuropeptide Y
- 分子量：
- 11kD
- 背景：
- This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014],
- 功能：
- function:NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.,online information:Neuropeptide Y entry,similarity:Belongs to the NPY family.,tissue specificity:One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.,
- 细胞定位：
- Secreted. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle .
- 组织表达：
- One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.
Stress aggravates and prolongs imiquimod‐induced psoriasis‐like epidermal hyperplasis and IL‐1β/IL‐23p40 production. JOURNAL OF LEUKOCYTE BIOLOGY J Leukocyte Biol. 2020 Jul;108(1):267-281 WB Mouse 1:500 Skin
货号：YT3182
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- Antibody-FAQs
- 产品图片
- Immunohistochemistry analysis of NPY antibody in paraffin-embedded human brain tissue.
