- 靶点：
- NK-1R
- 简介：
- >>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction
- 基因名称：
- TACR1
- 蛋白名称：
- Substance-P receptor
- Human Gene Id：
- 6869
- Human Swiss Prot No：
- P25103
- Mouse Gene Id：
- 21336
- Mouse Swiss Prot No：
- P30548
- Rat Gene Id：
- 24807
- Rat Swiss Prot No：
- P14600
- 免疫原：
- The antiserum was produced against synthesized peptide derived from human NK1R. AA range:211-260
- 特异性：
- NK-1R Polyclonal Antibody detects endogenous levels of NK-1R protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度：
- 1 mg/ml
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- TACR1;NK1R;TAC1R;Substance-P receptor;SPR;NK-1 receptor;NK-1R;Tachykinin receptor 1
- 实测条带：
- 50kD
- 背景：
- This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008],
- 功能：
- function:This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.,online information:Tachykinin entry,similarity:Belongs to the G-protein coupled receptor 1 family.,
- 细胞定位：
- Cell membrane; Multi-pass membrane protein.
- 组织表达：
- Brain,G-protein coupled receptors,Lung,Placenta,
He-Wei granules inhibit chemotherapy-induced vomiting (CINV) in rats by reducing oxidative stress and regulating 5-HT, substance P, ghrelin and obestatin. RSC Advances Rsc Adv. 2017 Sep;7(69):43866-43878 WB Rat ileum , medulla oblongata
货号：YT3131
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- Antibody-FAQs
- 产品图片
- Western Blot analysis of MOUSE-BRAIN COLO cells using NK-1R Polyclonal Antibody diluted at 1:1000
- Western blot analysis of lysates from Jurkat cells, using NK1R Antibody. The lane on the right is blocked with the synthesized peptide.
