• 靶点：
• NDUFA4

• 简介：
• >>Oxidative phosphorylation;>>Metabolic pathways;>>Thermogenesis;>>Retrograde endocannabinoid signaling;>>Non-alcoholic fatty liver disease;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Chemical carcinogenesis - reactive oxygen species;>>Diabetic cardiomyopathy

• 基因名称：
• NDUFA4

• 蛋白名称：
• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4

• Human Gene Id：
• 4697

• Human Swiss Prot No：
• O00483

• Mouse Gene Id：
• 17992

• Mouse Swiss Prot No：
• Q62425

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human NDUFA4. AA range:32-81

• 特异性：
• NDUFA4 Polyclonal Antibody detects endogenous levels of NDUFA4 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• NDUFA4;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4;Complex I-MLRQ;CI-MLRQ;NADH-ubiquinone oxidoreductase MLRQ subunit

• 实测条带：
• 9kD

• 背景：
• The protein encoded by this gene belongs to the complex I 9kDa subunit family. Mammalian complex I of mitochondrial respiratory chain is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [provided by RefSeq, Jul 2008],

• 功能：
• function:Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.,similarity:Belongs to the complex I NDUFA4 subunit family.,subunit:Mammalian complex I is composed of 45 different subunits.,

• 细胞定位：
• Mitochondrion inner membrane ; Single-pass membrane protein .

• 组织表达：
• Brain,Liver,

A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection. Cell Death & Disease Cell Death Dis. 2020 Dec;11(12):1-17 WB Human HPAEpiC cell
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