• 靶点：
• NBK

• 简介：
• >>Endocrine resistance

• 基因名称：
• BIK

• 蛋白名称：
• Bcl-2-interacting killer

• Human Gene Id：
• 638

• Human Swiss Prot No：
• Q13323

• Mouse Swiss Prot No：
• O70337

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human BIK. AA range:18-67

• 特异性：
• NBK Polyclonal Antibody detects endogenous levels of NBK protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• BIK;NBK;Bcl-2-interacting killer;Apoptosis inducer NBK;BIP1;BP4

• 实测条带：
• 30 25kD

• 背景：
• The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011],

• 功能：
• domain:Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.,function:Accelerates programmed cell death. Binding to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.,subcellular location:Around the nuclear envelope, and in cytoplasmic membranes.,

• 细胞定位：
• Endomembrane system; Single-pass membrane protein. Mitochondrion membrane ; Single-pass membrane protein . Around the nuclear envelope, and in cytoplasmic membranes.

• 组织表达：
• B-cell,Lymph,Lymphoid,

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