- 靶点：
- MIP-3β
- 简介：
- >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>NF-kappa B signaling pathway
- 基因名称：
- CCL19
- 蛋白名称：
- C-C motif chemokine 19
- Human Gene Id：
- 6363
- Human Swiss Prot No：
- Q99731
- Mouse Swiss Prot No：
- O70460
- 免疫原：
- Synthesized peptide derived from MIP-3β . at AA range: 20-100
- 特异性：
- MIP-3β Polyclonal Antibody detects endogenous levels of MIP-3β protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度：
- 1 mg/ml
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- CCL19;ELC;MIP3B;SCYA19;C-C motif chemokine 19;Beta-chemokine exodus-3;CK beta-11;Epstein-Barr virus-induced molecule 1 ligand chemokine;EBI1 ligand chemokine;ELC;Macrophage inflammatory protein 3 beta;MIP-3-beta;Small-inducible
- 分子量：
- 11kD
- 背景：
- This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014],
- 功能：
- function:May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant SCYA19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes.,online information:CCL19 entry,similarity:Belongs to the intercrine beta (chemokine CC) family.,tissue specificity:Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.,
- 细胞定位：
- Secreted.
- 组织表达：
- Expressed at high levels in the lymph nodes, thymus and appendix. Intermediate levels seen in colon and trachea, while low levels found in spleen, small intestine, lung, kidney and stomach.
CCL19 has potential to be a potential prognostic biomarker and a modulator of tumor immune microenvironment (TIME) of breast cancer: a comprehensive analysis based on TCGA database IHC Human 1:300 breast carcinoma tissue/
货号：YT2766
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- Antibody-FAQs
- 产品图片
- Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
