• 靶点：
• Mfn2

• 简介：
• >>Mitophagy - animal;>>NOD-like receptor signaling pathway;>>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases

• 基因名称：
• MFN2

• 蛋白名称：
• Mitofusin-2

• Human Gene Id：
• 9927

• Human Swiss Prot No：
• O95140

• Mouse Gene Id：
• 170731

• Mouse Swiss Prot No：
• Q80U63

• Rat Swiss Prot No：
• Q8R500

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Mfn2. AA range:354-403

• 特异性：
• Mfn2 Polyclonal Antibody detects endogenous levels of Mfn2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MFN2;CPRP1;KIAA0214;Mitofusin-2;Transmembrane GTPase MFN2

• 实测条带：
• 86kD

• 背景：
• This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:GTP + H(2)O = GDP + phosphate.,disease:Defects in MFN2 are the cause of Charcot-Marie-Tooth disease type 2A2 (CMT2A2) [MIM:609260]. CMT2A2 is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.,disease:Defects in MFN2 are the cause of Charcot-Marie-Tooth disease type 6 (CMT6) [MIM:601152]; also referred to as autosomal dominant hereditary motor and sensory n

• 细胞定位：
• Mitochondrion outer membrane ; Multi-pass membrane protein . Colocalizes with BAX during apoptosis. .

• 组织表达：
• Ubiquitous; expressed at low level. Highly expressed in heart and kidney.

Deubiquitinating Enzyme USP19 Regulates Ferroptosis and Mitochondrial Damage in SH-SY5Y Cells by Targeting the NOX4 Protein JOURNAL OF ALZHEIMERS DISEASE Yu Wenzhen WB Human SH-SY5Y cell,293T cell
货号：YT2740

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