MC4-R Polyclonal Antibody
- 货号:YT2675
- 应用:WB;IHC;IF;ELISA
- 种属:Human;Mouse;Rat
- 简介:
- >>Neuroactive ligand-receptor interaction
- 蛋白名称:
- Melanocortin receptor 4
- 免疫原:
- The antiserum was produced against synthesized peptide derived from human MC4R. AA range:281-330
- 特异性:
- MC4-R Polyclonal Antibody detects endogenous levels of MC4-R protein.
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- MC4R;Melanocortin receptor 4;MC4-R
- 背景:
- The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010],
- 功能:
- disease:Defects in MC4R are a cause of autosomal dominant obesity [MIM:601665].,function:Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase.,online information:Melanocortin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with ATRNL1.,tissue specificity:Brain, placental, and gut tissues.,
- 细胞定位:
- Cell membrane ; Multi-pass membrane protein .
- 组织表达:
- Brain, placental, and gut tissues.
![](/uploadfiles/PIC/yt2675_pic853318522.jpg)
- Western blot analysis of lysates from MCF-7 cells, using MC4R Antibody. The lane on the right is blocked with the synthesized peptide.
![](/uploadfiles/PIC/54-ihc-biantaoticm202207.jpg)
- Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).