• 靶点：
• MAP4

• 基因名称：
• MAP4

• 蛋白名称：
• Microtubule-associated protein 4

• Human Gene Id：
• 4134

• Human Swiss Prot No：
• P27816

• Mouse Gene Id：
• 17758

• Mouse Swiss Prot No：
• P27546

• Rat Gene Id：
• 367171

• Rat Swiss Prot No：
• Q5M7W5

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human MAP4. AA range:662-711

• 特异性：
• MAP-4 Polyclonal Antibody detects endogenous levels of MAP-4 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MAP4;Microtubule-associated protein 4;MAP-4

• 分子量：
• 121kD

• 实测条带：
• 121kD

• 背景：
• The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],

• 功能：
• alternative products:Additional isoforms seem to exist,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Non-neuronal microtubule-associated protein. Promotes microtubule assembly.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.,similarity:Contains 3 Tau/MAP repeats.,similarity:Contains 4 Tau/MAP repeats.,

• 细胞定位：
• Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center . Recruitment to microtubule is inhibited by microtubules polyglutamylation. .

• 组织表达：
• Bone marrow,Brain,Cerebellum,Colon carcinoma,Epithelium,Eye,Heart,Liver,Lym

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