• 靶点：
• MAO-A

• 简介：
• >>Glycine, serine and threonine metabolism;>>Arginine and proline metabolism;>>Histidine metabolism;>>Tyrosine metabolism;>>Phenylalanine metabolism;>>Tryptophan metabolism;>>Drug metabolism - cytochrome P450;>>Metabolic pathways;>>Serotonergic synapse;>>Dopaminergic synapse;>>Parkinson disease;>>Cocaine addiction;>>Amphetamine addiction;>>Alcoholism

• 基因名称：
• MAOA

• 蛋白名称：
• Amine oxidase [flavin-containing] A

• Human Gene Id：
• 4128

• Human Swiss Prot No：
• P21397

• Mouse Gene Id：
• 17161

• Mouse Swiss Prot No：
• Q64133

• Rat Swiss Prot No：
• P21396

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human MAO-A. AA range:298-347

• 特异性：
• MAO-A Polyclonal Antibody detects endogenous levels of MAO-A protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MAOA;Amine oxidase [flavin-containing] A;Monoamine oxidase type A;MAO-A

• 实测条带：
• 61kD

• 背景：
• This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012],

• 功能：
• catalytic activity:RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).,cofactor:FAD.,disease:Defects in MAOA are the cause of Brunner syndrome (BRUNS) [MIM:300615]. Brunner syndrome is a form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.,function:Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.,mass spectrometry: PubMed:11812236,online information:Monoamine oxidase entry,similarity:Belongs to

• 细胞定位：
• Mitochondrion outer membrane ; Single-pass type IV membrane protein ; Cytoplasmic side .

• 组织表达：
• Heart, liver, duodenum, blood vessels and kidney.

Alternate-day fasting ameliorated anxiety-like behavior in high-fat diet-induced obese mice JOURNAL OF NUTRITIONAL BIOCHEMISTRY Huijuan Hu WB Mouse 1:1000 hippocampal tissue
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