- 靶点:
- MALT1
- 简介:
- >>NF-kappa B signaling pathway;>>C-type lectin receptor signaling pathway;>>T cell receptor signaling pathway;>>B cell receptor signaling pathway;>>Shigellosis;>>Tuberculosis
- 基因名称:
- MALT1
- 蛋白名称:
- Mucosa-associated lymphoid tissue lymphoma translocation protein 1
- Human Gene Id:
- 10892
- Human Swiss Prot No:
- Q9UDY8
- Mouse Gene Id:
- 240354
- Mouse Swiss Prot No:
- Q2TBA3
- 免疫原:
- The antiserum was produced against synthesized peptide derived from human MALT1. AA range:301-350
- 特异性:
- MALT1 Polyclonal Antibody detects endogenous levels of MALT1 protein.
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Polyclonal, Rabbit,IgG
- 稀释:
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度:
- 1 mg/ml
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- MALT1;MLT;Mucosa-associated lymphoid tissue lymphoma translocation protein 1;MALT lymphoma-associated translocation;Paracaspase
- 实测条带:
- 90kD
- 背景:
- This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
- 功能:
- disease:A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.,function:Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL-10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.,similarity:Belongs to the peptidase C14B family.,similarity:Contains 1 death domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.,subunit:Binds through its Ig-like
- 细胞定位:
- Cytoplasm, perinuclear region . Nucleus . Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10. .
- 组织表达:
- Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.
MALT1 Protease Regulates T-Cell Immunity via the mTOR Pathway in Oral Lichen Planus INFLAMMATION Wang Xiao-Feng IHC Human 1:100 oral mucosa tissue
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- Antibody-FAQs
- 产品图片
- Western Blot analysis of HUVEC cells using MALT1 Polyclonal Antibody
- Immunohistochemical analysis of paraffin-embedded Human breast cancer. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
- Western blot analysis of lysates from HUVEC cells, using MALT1 Antibody. The lane on the right is blocked with the synthesized peptide.