• 靶点：
• Malic enzyme 1

• 简介：
• >>Pyruvate metabolism;>>Metabolic pathways;>>Carbon metabolism;>>PPAR signaling pathway

• 基因名称：
• ME1

• 蛋白名称：
• NADP-dependent malic enzyme

• Human Gene Id：
• 4199

• Human Swiss Prot No：
• P48163

• Mouse Gene Id：
• 17436

• Mouse Swiss Prot No：
• P06801

• Rat Swiss Prot No：
• P13697

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human ME1. AA range:468-517

• 特异性：
• Malic enzyme 1 Polyclonal Antibody detects endogenous levels of Malic enzyme 1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ME1;NADP-dependent malic enzyme;NADP-ME;Malic enzyme 1

• 实测条带：
• 64kD

• 背景：
• This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH.,cofactor:Divalent metal cations. Prefers magnesium or manganese.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the malic enzymes family.,subunit:Homotetramer.,tissue specificity:Expressed in all tissues tested including liver, placenta and white adipose tissue.,

• 细胞定位：
• Cytoplasm .

• 组织表达：
• Expressed in all tissues tested including liver, placenta and white adipose tissue.

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