• 靶点：
• Kv1.3

• 基因名称：
• KCNA3

• 蛋白名称：
• Potassium voltage-gated channel subfamily A member 3

• Human Gene Id：
• 3738

• Human Swiss Prot No：
• P22001

• Mouse Gene Id：
• 16491

• Mouse Swiss Prot No：
• P16390

• Rat Gene Id：
• 29731

• Rat Swiss Prot No：
• P15384

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human Kv1.3/KCNA3. AA range:101-150

• 特异性：
• Kv1.3 Polyclonal Antibody detects endogenous levels of Kv1.3 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• KCNA3;HGK5;Potassium voltage-gated channel subfamily A member 3;HGK5;HLK3;HPCN3;Voltage-gated K(+) channel HuKIII;Voltage-gated potassium channel subunit Kv1.3

• 分子量：
• 58kD

• 背景：
• Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and

• 功能：
• caution:It is uncertain whether Met-1 or Met-53 is the initiator.,domain:The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.,domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the potassium channel family. A (Shaker) subfamily.,subunit

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein.

• 组织表达：
• Blood,Brain,Lymphocyte,Skeletal muscle,

Geraniol targets KV1.3 ion channel and exhibits anti-inflammatory activity in vitro and in vivo. FITOTERAPIA 2019 Oct 25 WB Human Jurkat cell
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