• 靶点：
• KIR2.1

• 简介：
• >>Cholinergic synapse;>>Oxytocin signaling pathway;>>Renin secretion;>>Gastric acid secretion

• 基因名称：
• KCNJ2

• 蛋白名称：
• Inward rectifier potassium channel 2

• Human Gene Id：
• 3759

• Human Swiss Prot No：
• P63252

• Mouse Swiss Prot No：
• P35561

• Rat Gene Id：
• 29712

• Rat Swiss Prot No：
• Q64273

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human KCNJ2. AA range:81-130

• 特异性：
• KIR2.1 Polyclonal Antibody detects endogenous levels of KIR2.1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• KCNJ2;IRK1;Inward rectifier potassium channel 2;Cardiac inward rectifier potassium channel;Inward rectifier K(+) channel Kir2.1;IRK-1;hIRK1;Potassium channel; inwardly rectifying subfamily J member 2

• 实测条带：
• 48kD

• 背景：
• Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. [provided by RefSeq, Jul 2008],

• 功能：
• disease:Defects in KCNJ2 are the cause of long QT syndrome type 7 (LQT7) [MIM:170390]; also called Andersen syndrome or Andersen cardiodysrhythmic periodic paralysis. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. LQT7 manifests itself as a clinical triad consisting of potassium-sensitive periodic paralysis, ventricular ectopy and dysmorphic features.,disease:Defects in KCNJ2 are the cause of short QT syndrome type 3 (SQT3) [MIM:609622]. Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death. SQT3 has a unique ECG phenotype characterized by asymmetrical T wave

• 细胞定位：
• Membrane; Multi-pass membrane protein. Membrane; Lipid-anchor .

• 组织表达：
• Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.

The use of antibody modified liposomes loaded with AMO-1 to deliver oligonucleotides to ischemic myocardium for arrhythmia therapy. BIOMATERIALS Biomaterials. 2014 Apr;35:3697 IHC Rat 1:100 left ventricle
货号：YT2473

The use of antibody modified liposomes loaded with AMO-1 to deliver oligonucleotides to ischemic myocardium for arrhythmia therapy. BIOMATERIALS Biomaterials. 2014 Apr;35:3697 IHC Rat 1:100 left ventricle
货号：YT2473

• June 19-2018
• WESTERN IMMUNOBLOTTING PROTOCOL

• June 19-2018
• IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL

• June 19-2018
• IMMUNOFLUORESCENCE PROTOCOL

• September 08-2020
• FLOW-CYTOMEYRT-PROTOCOL

• May 20-2022
• Cell-Based ELISA│解您多样本WB检测之困扰

• July 13-2018
• CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN

• July 13-2018
• CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN

• July 13-2018
• CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN

• July 13-2018
• Antibody-FAQs