- 靶点：
- IRAK-2
- 简介：
- >>Neurotrophin signaling pathway;>>Tuberculosis
- 基因名称：
- IRAK2
- 蛋白名称：
- Interleukin-1 receptor-associated kinase-like 2
- Human Gene Id：
- 3656
- Human Swiss Prot No：
- O43187
- Mouse Swiss Prot No：
- Q8CFA1
- 免疫原：
- Synthesized peptide derived from the Internal region of human IRAK-2.
- 特异性：
- IRAK-2 Polyclonal Antibody detects endogenous levels of IRAK-2 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:500-2000;IHC 1:50-300
- 纯化工艺：
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 浓度：
- 1 mg/ml
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- IRAK2;Interleukin-1 receptor-associated kinase-like 2;IRAK-2
- 实测条带：
- 70kD
- 背景：
- IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008],
- 功能：
- caution:Asn-335 is present instead of the conserved Asp which is expected to be an active site residue. This enzyme has been shown to be catalytically inactive.,domain:The protein kinase domain is predicted to be catalytically inactive.,function:Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.,similarity:Contains 1 death domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.,tissue specificity:Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leuko
- 细胞定位：
- nucleus,cytoplasm,cytosol,plasma membrane,endosome membrane,
- 组织表达：
- Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes.
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- Antibody-FAQs
- 产品图片
- Western Blot analysis of various cells using IRAK-2 Polyclonal Antibody diluted at 1:2000
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- Western Blot analysis of 293 cells using IRAK-2 Polyclonal Antibody diluted at 1:2000
- Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
