• 靶点：
• IP3KA

• 简介：
• >>Inositol phosphate metabolism;>>Metabolic pathways;>>Calcium signaling pathway;>>Phosphatidylinositol signaling system

• 基因名称：
• ITPKA

• 蛋白名称：
• Inositol-trisphosphate 3-kinase A

• Human Gene Id：
• 3706

• Human Swiss Prot No：
• P23677

• Mouse Gene Id：
• 228550

• Mouse Swiss Prot No：
• Q8R071

• Rat Gene Id：
• 81677

• Rat Swiss Prot No：
• P17105

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human IP3KA. AA range:396-445

• 特异性：
• IP3KA Polyclonal Antibody detects endogenous levels of IP3KA protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ITPKA;Inositol-trisphosphate 3-kinase A;Inositol 1;4,5-trisphosphate 3-kinase A;IP3 3-kinase A;IP3K A;InsP 3-kinase A

• 实测条带：
• 52kD

• 背景：
• Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011],

• 功能：
• catalytic activity:ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.,enzyme regulation:IP3K is activated by calmodulin.,similarity:Belongs to the inositol phosphokinase (IPK) family.,

• 细胞定位：
• Cytoplasm, cytoskeleton .

• 组织表达：
• Expressed in brain.

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