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IP-10 Polyclonal Antibody

货号：YT2379
应用：IHC;IF;ELISA
种属：Human;Pig;chiken

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靶点：
IP-10

简介：
>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>Toll-like receptor signaling pathway;>>RIG-I-like receptor signaling pathway;>>Cytosolic DNA-sensing pathway;>>IL-17 signaling pathway;>>TNF signaling pathway;>>Hepatitis C;>>Influenza A;>>Epstein-Barr virus infection;>>Coronavirus disease - COVID-19

基因名称：
CXCL10

蛋白名称：
C-X-C motif chemokine 10

Human Gene Id：
3627

Human Swiss Prot No：
P02778

Mouse Swiss Prot No：
P17515

免疫原：
Synthesized peptide derived from IP-10 . at AA range: 20-100

特异性：
IP-10 Polyclonal Antibody detects endogenous levels of IP-10 protein.

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
CXCL10;INP10;SCYB10;C-X-C motif chemokine 10;10 kDa interferon gamma-induced protein;Gamma-IP10;IP-10;Small-inducible cytokine B10

分子量：
11kD

背景：
C-X-C motif chemokine ligand 10(CXCL10) Homo sapiens This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014],

功能：
function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.,induction:By interferon gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the interferon gamma response.,mass spectrometry: PubMed:11559369,online information:CXCL10 entry,PTM:CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,

细胞定位：
Secreted .

组织表达：
Mainly secreted by monocytes, endothelial cells as well as fibroblasts. Expressed by epithelial cells in thymus (PubMed:11157474). Microglial cells produce CXCL10 in response to viral stimulation (PubMed:12663757).

An ultrasensitive and long-lasting chemiluminescence immunoassay for IP-10 detection based on a 4-bromophenol-reinforced bienzymatic system WB Human Blood/
货号：YT2379