ImmunoWay Biotechnology Company |抗体|病理抗体|诊断抗体

IL-4 Polyclonal Antibody

货号：YT2335
应用：WB;FCM;ELISA
种属：Human;Mouse

产品详情
文献 ( 1 )
操作手册

靶点：
IL-4

简介：
>>Cytokine-cytokine receptor interaction;>>PI3K-Akt signaling pathway;>>JAK-STAT signaling pathway;>>Hematopoietic cell lineage;>>IL-17 signaling pathway;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>T cell receptor signaling pathway;>>Fc epsilon RI signaling pathway;>>Intestinal immune network for IgA production;>>Leishmaniasis;>>Pathways in cancer;>>Asthma;>>Autoimmune thyroid disease;>>Inflammatory bowel disease;>>Allograft rejection

基因名称：
IL4

蛋白名称：
Interleukin-4

Human Gene Id：
3565

Human Swiss Prot No：
P05112

Mouse Swiss Prot No：
P07750

免疫原：
Synthesized peptide derived from the C-terminal region of human IL-4.

特异性：
IL-4 Polyclonal Antibody detects endogenous levels of IL-4 protein.

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
WB 1:500-2000;Flow Cyt 1:50-200;ELISA 1:5000-20000

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
IL4;Interleukin-4;IL-4;B-cell stimulatory factor 1;BSF-1;Binetrakin;Lymphocyte stimulatory factor 1;Pitrakinra

实测条带：
18kD

背景：
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],

功能：
disease:Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.,function:Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes

细胞定位：
Secreted.

组织表达：
Blood,PCR rescued clones,

Effect of montelukast combined with methylprednisolone for the treatment of mycoplasma pneumonia:. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 2019 May 09 FC Human T cell
货号：YT2335