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IL-21 Polyclonal Antibody

货号：YT2327
应用：WB;ELISA
种属：Human;Mouse

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靶点：
IL-21

简介：
>>Cytokine-cytokine receptor interaction;>>JAK-STAT signaling pathway;>>Th17 cell differentiation;>>Inflammatory bowel disease

基因名称：
IL21

蛋白名称：
Interleukin-21

Human Gene Id：
59067

Human Swiss Prot No：
Q9HBE4

Mouse Gene Id：
60505

Mouse Swiss Prot No：
Q9ES17

免疫原：
The antiserum was produced against synthesized peptide derived from human IL21. AA range:91-140

特异性：
IL-21 Polyclonal Antibody detects endogenous levels of IL-21 protein.

组成：
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

来源：
Polyclonal, Rabbit,IgG

稀释：
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

纯化工艺：
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度：
1 mg/ml

储存：
-15°C to -25°C/1 year(Do not lower than -25°C)

其他名称：
IL21;Interleukin-21;IL-21;Za11

实测条带：
18kD

背景：
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],

功能：
function:Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.,similarity:Belongs to the IL-15/IL-21 family.,tissue specificity:Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.,

细胞定位：
Secreted .

组织表达：
Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.

Oxymatrine ameliorates rheumatoid arthritis by regulation of Tfr/Tfh cells balance via TLR9-MyD88-STAT3 signaling pathway. Yanli Zhang WB Mouse joint synovial tissue
货号：YT2327