• 靶点：
• IL-11

• 简介：
• >>Cytokine-cytokine receptor interaction;>>JAK-STAT signaling pathway;>>Hematopoietic cell lineage;>>Rheumatoid arthritis

• 基因名称：
• IL11

• 蛋白名称：
• Interleukin-11

• Human Gene Id：
• 3589

• Human Swiss Prot No：
• P20809

• Mouse Gene Id：
• 16156

• Mouse Swiss Prot No：
• P47873

• Rat Swiss Prot No：
• Q99MF5

• 免疫原：
• The antiserum was produced against synthesized peptide derived from human IL-11. AA range:27-76

• 特异性：
• IL-11 Polyclonal Antibody detects endogenous levels of IL-11 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Polyclonal, Rabbit,IgG

• 稀释：
• IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• IL11;Interleukin-11;IL-11;Adipogenesis inhibitory factor;AGIF;Oprelvekin

• 分子量：
• 21kD

• 背景：
• The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012],

• 功能：
• function:Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.,online information:Clinical information on Neumega,online information:Interleukin-11 entry,pharmaceutical:Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.,similarity:Belongs to the IL-6 superfamily.,

• 细胞定位：
• Secreted .

• 组织表达：
• Bone marrow,Prostate,

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